منابع مشابه
Cardiac Arrhythmia 1 Systems biology and cardiac arrhythmias
During the past few years, the development of effective, empirical technologies for treatment of cardiac arrhythmias has exceeded the pace at which detailed knowledge of the underlying biology has accumulated. As a result, although some clinical arrhythmias can be cured with techniques such as catheter ablation, drug treatment and prediction of the risk of sudden death remain fairly primitive. ...
متن کاملCardiac systems biology.
As more detailed molecular information accumulates on the biology of the heart and other complex systems in health and disease, the need for new integrative analyses and tools is growing. Systems biology and bioengineering seek to use high-throughput technologies and integrative computational analysis to construct networks of the interactions between molecular components in the system, to devel...
متن کاملComputational Biology of cardiac arrhythmias: from basic science to application
Cardiac virtual tissues are biophysically, histologically and anatomically detailed computational models that are sufficiently well validated to be used as a predictive tool, are currently used in basic research, and are beginning to be applied to clinical problems. Virtual cardiac cells and tissues are stiff, high order ordinary and partial differential equations. While 1and 2-D tissues can be...
متن کاملCardiac Rhythms and Arrhythmias
node as the region responsible for activation of the heart.1 Laslett first suggested sinus node dysfunction as a cause of bradycardia in 1909, and during the 1950s and 1960s Short, Ferrer, Lown, and others described the clinical spectrum of sinus node dysfunction that is commonly called the “sick sinus syndrome resting sinus bradycardia.”2-5 Sinus node dysfunction can have multiple electrocardi...
متن کاملStress and Cardiac Arrhythmias
Stress can exert adverse effect on cardiovascular health. Psychosocial stress adversely affects the autonomic homeostasis. This in turn can result in metabolic abnormalities, inflammation and dysfunction of endothelium [1]. Changes in the autonomic homeostasis can be a major trigger for ventricular tachyarrhythmias [2]. Increased sympathetic nervous activity can cause increased proarrhythmic re...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2012
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(12)61462-7